Antidiabetic Drugs

Diabetes mellitus is a chronic disease characterized by elevated blood glucose levels, resulting from either a lack of insulin production (Type 1 diabetes) or resistance to insulin (Type 2 diabetes). Proper management of diabetes involves lifestyle modifications and the use of pharmacological agents to control blood sugar levels. There are several classes of antidiabetic drugs, each with distinct mechanisms of action, benefits, and potential side effects.

This category  provides a detailed overview of the most common antidiabetic drugs, categorized by drug class, and outlines their specifications. It includes information such as their mechanism of action, half-life, excretion route, HbA1C reduction, risk of hypoglycemia, body weight effects, cardiovascular benefit/risk, and any additional adverse effects. Additionally, we will explore the different types of anti-diabetic agents, examples of drugs in each category, and brief explanations.

Main Types of Anti-Diabetic Agents

The main classes of anti-diabetic drugs include:

  1. Insulin and Insulin Analogues
  2. Biguanides (e.g., Metformin)
  3. Sulfonylureas (e.g., Glibenclamide)
  4. DPP-4 Inhibitors (e.g., Sitagliptin)
  5. GLP-1 Receptor Agonists (e.g., Liraglutide)
  6. SGLT-2 Inhibitors (e.g., Empagliflozin)
  7. Thiazolidinediones (e.g., Pioglitazone)
  8. Alpha-glucosidase Inhibitors (e.g., Acarbose)
  9. Meglitinides (e.g., Repaglinide)

Dapagliflozin-Farxiga – SGLT-2 inhibitor

Farxiga-dapagliflozin

Dapagliflozin is a pharmaceutical agent indicated for the management of type 2 diabetes, heart failure, and chronic kidney disease (CKD). It belongs to the class of sodium-glucose cotransporter-2 (SGLT-2) inhibitors, which have proven effective in lowering blood glucose levels and offering additional cardiovascular and renal benefits. Mechanism of Action of …

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Empagliflozin- An SGLT-2 Inhibitor

What is Empagliflozin? Empagliflozin is an antidiabetic medication classified as a Na-glucose co-transporter 2 (SGLT-2) inhibitor. It is primarily used for managing type 2 diabetes and offers additional benefits for heart failure and chronic kidney disease. Mechanism of Action Empagliflozin perform its work by inhibiting the SGLT-2 protein in the …

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Tolbutamide

tolbutamide

Tolbutamide is a first-generation sulfonylurea medication commonly used to manage type 2 diabetes mellitus. It helps lower blood sugar levels by stimulating the release of insulin from the pancreas. This article covers the pharmacokinetics, pharmacodynamics, uses, side effects, contraindications, drug-drug interactions, and a table of popular brand names with specifications. …

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Chlorpropamide- A Sulfonylurea Antidiabetic Drug

Chlorpropamide is a medication belonging to the sulfonylurea class, primarily used in the management of type 2 diabetes. This article explores the drug’s mechanism of action, uses, side effects, contraindications, drug interactions, and provides a table listing its popular brand names, dosages, and specifications. Table of Contents Introduction Mechanism of …

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Sulfonylureas to manage type 2 diabetes mellitus

 Sulfonylureas are a class of oral antidiabetic medications primarily used to manage type 2 diabetes mellitus. They work by stimulating the pancreas to release more insulin, thereby helping to control blood sugar levels. Mechanism of Action Sulfonylureas exert their effect by binding to specific receptors on the pancreatic beta cells, …

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Understanding the Importance of Insulin in Diabetes

Insulin is one of the most crucial hormones in the body, especially for individuals with diabetes. It regulates blood sugar levels and is essential for maintaining overall health. This article provides a thorough understanding of insulin, including its definition, importance, manufacturing process, various types, uses, side effects, and safety precautions. …

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Antidiabetic Drugs – Anti-hyperglycemic drugs

Diabetes mellitus is a chronic disease characterized by elevated blood glucose levels, resulting from either a lack of insulin production (Type 1 diabetes) or resistance to insulin (Type 2 diabetes). Proper management of diabetes involves lifestyle modifications and the use of pharmacological agents to control blood sugar levels. There are …

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