Pharmacistsite.com Empowering Your Health
Tolbutamide is a first-generation sulfonylurea medication commonly used to manage type 2 diabetes mellitus. It helps lower blood sugar levels by stimulating the release of insulin from the pancreas. This article covers the pharmacokinetics, pharmacodynamics, uses, side effects, contraindications, drug-drug interactions, and a table of popular brand names with specifications. …
Read More »Sulfonylureas are a class of oral hypoglycemic drugs used primarily in the treatment of type 2 diabetes. They work by stimulating the pancreas to release more insulin, thereby lowering blood glucose levels. Sulfonylureas bind to specific receptors on pancreatic beta cells, inhibiting potassium channels, which leads to cell depolarization and insulin secretion. Common examples include glibenclamide, glipizide, and gliclazide. While effective, sulfonylureas can cause side effects like hypoglycemia and weight gain. They are typically used when lifestyle changes and other medications, like metformin, are insufficient in controlling blood glucose.
