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Cetirizine and loratadine are both popular antihistamines used to treat allergy symptoms such as sneezing, runny nose, and itchy eyes. While they belong to the same class of drugs (second-generation antihistamines), they have some differences in their effects, side effects, and uses. Cetirizine vs Loratadine comparison is given below.
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Overview
| Feature | Cetirizine | Loratadine |
|---|---|---|
| Class of Drug | Second-generation antihistamine | Second-generation antihistamine |
| Brand Names | Zyrtec, Reactine | Claritin, Alavert |
| Common Uses | Allergies, hay fever, hives | Allergies, hay fever, itching |
| Drug Type | Oral tablet, syrup, chewable | Oral tablet, syrup, chewable |
Mechanism of Action
Both cetirizine and loratadine work by blocking histamine receptors (H1 receptors) in the body, reducing allergic reactions. However, cetirizine has a slightly stronger sedating effect, which can make it more effective for severe allergic reactions.
Key Differences
| Characteristic | Cetirizine | Loratadine |
|---|---|---|
| Onset of Action | 1 hour | 1-3 hours |
| Duration of Action | 24 hours | 24 hours |
| Sedation | Mild sedation (more than loratadine) | Non-sedating (less sedative effect) |
| Metabolism | Primarily metabolized by liver | Primarily metabolized by liver |
| Excretion | Excreted in urine | Excreted in urine |
| Use in Children | Safe for children aged 2 years and older | Safe for children aged 2 years and older |
| Pregnancy Category | Category B (safe for use in pregnancy) | Category B (safe for use in pregnancy) |
Side Effects Cetirizine vs Loratadine
| Side Effect | Cetirizine | Loratadine |
|---|---|---|
| Common Side Effects | Drowsiness, dry mouth, headache | Headache, dry mouth, drowsiness (rare) |
| Serious Side Effects | Fast heartbeat, swelling, difficulty breathing | Fast heartbeat, rash, severe dizziness |
Which One to Choose?
Cetirizine vs Loratadine?
- Cetirizine may be preferred for those who need faster relief from allergy symptoms, particularly in severe cases, as it is slightly more sedating.
- Loratadine is ideal for individuals who need to avoid drowsiness or who have less severe symptoms.
Conclusion
Both cetirizine and loratadine are effective for managing allergies with minimal side effects. The choice between the two will depend on individual needs, particularly regarding the sedative effects and the severity of symptoms. Always consult a healthcare provider before choosing the most suitable option for your condition.
